Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia |
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| Authors: | H Kurisu K Kamisaka T Koyo S Yamasuge H Igarashi H Maezawa T Uesugi O Tagaya |
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| Institution: | Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan. |
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| Abstract: | The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophtalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n = 4) in adult rats, with 97% conjugates. The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities. |
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