Coherent pipeline for biomarker discovery using mass spectrometry and bioinformatics |
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Authors: | Ali Al-Shahib Raju Misra Nadia Ahmod Min Fang Haroun Shah Saheer Gharbia |
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Institution: | (1) Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London, NW9 5EQ, UK |
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Abstract: | Background Robust biomarkers are needed to improve microbial identification and diagnostics. Proteomics methods based on mass spectrometry
can be used for the discovery of novel biomarkers through their high sensitivity and specificity. However, there has been
a lack of a coherent pipeline connecting biomarker discovery with established approaches for evaluation and validation. We
propose such a pipeline that uses in silico methods for refined biomarker discovery and confirmation. |
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