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A Targeted Proteomics Approach for Biomarker Discovery Using Bilateral Matched Nipple Aspiration Fluids

Authors:	Jinong Li Junma Zhou Bruce Trock Theodore N Tsangaris Neil B Friedman Deanna Shapiro Michelle Brotzman Daniel W Chan

Institution:	1.Department of Pathology,Johns Hopkins Medical Institutions,Baltimore,USA;2.Department of Urology,Johns Hopkins Medical Institutions,Baltimore,USA;3.Department of Surgery,Johns Hopkins Medical Institutions,Baltimore,USA;4.Hoffberger Breast Center at Mercy Hospital,Baltimore,USA

Abstract:	Introduction The objective of this study was to identify cancer-associated protein expression patterns in bilateral matched nipple aspiration fluids using nanoscale reciprocal Cy3/Cy5 labeling and high-content antibody microarrays. This novel platform allows the pair-wise comparisons of the relative abundance of 512 different antigens using minimal NAF sample containing 1 μg of total protein.

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