Functional conservation of a forebrain enhancer from the elephant shark (<Emphasis Type="Italic">Callorhinchus milii</Emphasis>) in zebrafish and mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii) in zebrafish and mice

Authors:	Ryan B MacDonald Mélanie Debiais-Thibaud Kyle Martin Luc Poitras Boon-Hui Tay Byrappa Venkatesh Marc Ekker

Affiliation:	(1) Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, K1N 6N5 Ottawa, ON, Canada;(2) Institute of Molecular and Cell Biology, A*STAR, 138673 Biopolis, Singapore;(3) Department of Zoology, Oxford University, Oxford, UK

Abstract:	Background The phylogenetic position of the elephant shark (Callorhinchus milii ) is particularly relevant to study the evolution of genes and gene regulation in vertebrates. Here we examine the evolution of Dlx homeobox gene regulation during vertebrate embryonic development with a particular focus on the forebrain. We first identified the elephant shark sequence orthologous to the URE2 cis -regulatory element of the mouse Dlx1/Dlx2 locus (herein named CmURE2). We then conducted a comparative study of the sequence and enhancer activity of CmURE2 with that of orthologous regulatory sequences from zebrafish and mouse.

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