Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa |
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| Authors: | Choi Dong-Sic Kim Dae-Kyum Choi Seng Jin Lee Jaewook Choi Jun-Pyo Rho Sangchul Park Sang-Hyun Kim Yoon-Keun Hwang Daehee Gho Yong Song |
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| Affiliation: | Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea. |
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| Abstract: | Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress has revealed that OMVs are essential for pathogenesis of P. aeruginosa, their proteins have not been comprehensively analyzed so far. In this study, we identified 338 vesicular proteins with high confidence by five separate LC-MS/MS analyses. This global proteome profile provides a basis for future studies to elucidate the pathological functions of OMVs from P. aeruginosa. |
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| Keywords: | Microbiology Outer membrane vesicles Pseudomonas aeruginosa Vaccine |
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