Phosphatidylcholine synthesis in adult Dirofilaria immitis females |
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Authors: | A K Srivastava J J Jaffe |
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Affiliation: | Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, U.S.A. |
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Abstract: | Crude homogenates of adult Dirofilaria immitis females were able to incorporate choline into phosphatidylcholine (PC) and also were able to methylate phosphatidyl (N,N-dimethyl)-ethanolamine, using S-adenosylmethionine as the methyl donor, to form PC. The finding of choline phosphotransferase (EC 2·7·8·2) and phosphatidyl (N,N-dimethyl) ethanolamine methyltransferase activity in the paniculate (mainly microsomal) fraction of the homogenates provided further evidence that adult D. immitis females can synthesize PC by way of choline and cytidine 5'-diphosphocholine (Kennedy pathway) and also by way of S-adenosylmethionine-mediated sequential methylation of phosphatidylethanolamine (Bremer-Greenberg pathway). |
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Keywords: | phospholipids, phosphatidylcholine phosphotransferase Kennedy pathway Bremer-Greenberg pathway |
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