Changes in the outer mitochondrial membranes during apoptosis |
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| Authors: | Lucken-Ardjomande Safa Montessuit Sylvie Martinou Jean-Claude |
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| Institution: | Département de biologie cellulaire, Université de Genève, 30, quai Ernest-Ansermet, 1211 Genève 4, Suisse. |
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| Abstract: | Mitochondria are involved in many apoptotic responses. Following permeabilization of their outer membrane, they release many apoptogenic proteins, including cytochrome c, which contribute to caspase activation. The mechanisms responsible for membrane permeability are not completely understood. Here, we briefly review the mechanisms that have been proposed to explain this phenomenon. |
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