Distribution of two hemolytic toxin genes in clinical and environmental isolates of Aeromonas spp.: correlation with virulence in a suckling mouse model |
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Authors: | Heuzenroeder M W Wong C Y Flower R L |
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Affiliation: | Infectious Disease Laboratory, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. heuzenroeder@imvs.sa.gov.au |
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Abstract: | Previous studies have shown that two hemolytic toxins, HlyA and AerA, contribute to the virulence of Aeromonas hydrophila. A survey was performed to gauge the distribution of hlyA and aerA genes in clinical and environmental Aeromonas isolates. For A. hydrophila, A. veronii biotype sobria and A caviae, 96%, 12% and 35% of strains, respectively, were hlyA positive, whereas, 78%, 97%, 41%, respectively, were aerA positive. All virulent A. hydrophila isolates were hlyA+ aerA+. This genotype was most common in A. hydrophila (75.4%) followed by A. caviae (29.4%) and A. veronii biotype sobria (9.6%). For A. hydrophila, a two-hemolytic toxin model of virulence provides the best prediction of virulence in an animal model. |
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Keywords: | Aeromonas Aerolysin Hemolysin Cytotoxin Virulence |
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