Acknowledgment |
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Authors: | SN Chen RE Howells |
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Institution: | Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, England, U.K. |
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Abstract: | The uptake and incorporation in vitro of various nucleic acid precursors by microfilariae, third-stage infective larvae, 10-day-old juveniles and adult worms of Brugia pahangi were investigated using scintillation counting and autoradiographic techniques. A significant uptake of uracil and of purines, including adenine, hypoxanthine, and guanine was demonstrated in this study. No evidence was obtained for the uptake and incorporation of thymine, cytosine, orotate, formate, folate or p-aminobenzoic acid by either micro- or macrofilariae of B. pahangi. |
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Keywords: | Nematode parasitic Uptake Incorporation Purines Pyrimidines Nucleic acid precursors Microfilariae Macrofilariae |
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