Schistosoma mansoni: Anodic polysaccharide antigen in glomerular immune deposits of mice with unisexual infections |
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Authors: | E.A.E. van Marck A.M. Deelder P.L.J. Gigase |
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Affiliation: | Department of Histopathology and Experimental Schistosomiasis, Prince Leopold Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium;Department of Parasitology, Medical Center, Leiden University, Rapenburg 33, Leiden, The Netherlands;Department of Histopathology and Experimental Schistosomiasis, Prince Leopold Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium |
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Abstract: | In mice infected with unisexual Schistosoma mansoni, circulating anodic antigen was detected by immunofluorescence in glomeruli of 20 out of 22 animals from 7 to 30 weeks after infection. Circulating anodic antigen was present as finely granular deposits in the mesangium. The amount of circulating anodic antigen in the glomeruli was not clearly related to the worm burden but it increased during the course of the infection. These circulating anodic antigen deposits were accompanied by deposits of immunoglobulins, sometimes found in the same precise localization, and of complement. They probably represent the antigen part of immune complexes. Circulating anodic antigen appears to be a major candidate among the antigens involved in schistosomal glomerulopathy. |
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Keywords: | Trematode Blood fluke Mouse Unisexual infection Polysaccharide antigens Antigen, circulating anodic Immune complexes Immunofluorescence Kidney Glomeruli |
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