Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups |
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| Authors: | Chen James M Jin Guixian Sung Amy Levin Jeremy I |
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| Affiliation: | Wyeth-Ayerst Research, 401N. Middletown Road, Pearl River, NY 10965, USA. jchen@gilead.com |
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| Abstract: | The structure-based design of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups has led to compounds with excellent in vitro potency against TACE and selectivity over MMP-1. |
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