Computational protein design |
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Authors: | Christina M Kraemer-Pecore Andrew M Wollacott John R Desjarlais |
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Institution: | The Pennsylvania State University, Department of Chemistry, Chandlee Laboratory, University Park, PA 16802, USA. |
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Abstract: | The field of computational protein design is reaching its adolescence. Protein design algorithms have been applied to design or engineer proteins that fold, fold faster, catalyze, catalyze faster, signal, and adopt preferred conformational states. Further developments of scoring functions, sampling strategies, and optimization methods will expand the range of applicability of computational protein design to larger and more varied systems, with greater incidence of success. Developments in this field are beginning to have significant impact on biotechnology and chemical biology. |
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Keywords: | Computational protein design optimization scoring function sequence prediction protein combinatorial libraries |
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