Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis |
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| Authors: | Dimitrios Daoussis Vasileios Panoulas Tracey Toms Holly John Ioannis Antonopoulos Peter Nightingale Karen MJ Douglas Rainer Klocke George D Kitas |
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| Affiliation: | (1) Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK;(2) Wolfson Laboratory, Department of Medical Statistics, Queen Elizabeth Medical Centre, School of Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TH, UK;(3) Arthritis Research Campaign Epidemiology Unit, University of Manchester, Oxford Road, Stopford Building, Manchester, M13 9PT, UK |
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| Abstract: | Introduction Recent evidence suggests that uric acid (UA), regardless of crystal deposition, may play a direct pathogenic role in renal disease. We have shown that UA is an independent predictor of hypertension and cardiovascular disease (CVD), and that CVD risk factors associate with renal dysfunction, in patients with rheumatoid arthritis (RA). In this study we investigated whether UA associates with renal dysfunction in patients with RA and whether such an association is independent or mediated through other comorbidities or risk factors for renal impairment. |
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