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Randomized codon mutagenesis reveals that the HIV Rev arginine‐rich motif is robust to substitutions and that double substitution of two critical residues alters specificity |
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| Authors: | Elite J Possik Maroun S Bou Sleiman Ingrid R Ghattas Colin A Smith |
| Institution: | 1. McGill Cancer Centre and Department of Biochemistry, McGill University, , Montreal, Quebec, Canada;2. Doctoral Program in Molecular Life Sciences, Ecole Polytechnique Fédérale de Lausanne, , Lausanne, Switzerland;3. Department of Biology, American University of Beirut, , Beirut, Lebanon |
| Abstract: | |
| Keywords: | HIV rev Rev‐response element Rev aptamer I Protein– RNA recognition arginine‐rich motif neutral evolution |