| 多肽配体技术在植物功能基因组学中的应用前景 |
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| 引用本文： | 公丕昌,王丽,贺超英.多肽配体技术在植物功能基因组学中的应用前景[J].遗传,2010,32(6):548-554. |
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| 作者姓名： | 公丕昌 王丽 贺超英 |
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| 作者单位： | 中国科学院植物研究所, 系统与进化植物学国家重点实验室, 北京100093 |
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| 基金项目： | 国家转基因生物新品种培育科技重大专项 |
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| 摘 要： | 人工智能配体或适配体(Aptamer)技术是近年来兴起的一项特异性极强的基因干扰技术。通过人工合成特异的智能配体结合靶基因的蛋白产物, 达到特异干扰靶基因的生物学功能, 这是人工智能配体技术的基本设想。文章综述了多肽配体(Peptide aptamer)技术在基因功能验证中的主要进展, 着重阐明它在植物基因功能验证和作物抗病毒育种中的应用前景, 并提出克服该技术主要风险对策。
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| 关 键 词： | 多肽配体技术 化学遗传学 蛋白干扰 功能基因组学 |
| 收稿时间： | 2009-10-29 |
Peptide aptamer: a powerful potential tool in plant functional genomics |
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| GONG Pi-Chang,WANG Li,HE Chao-Ying.Peptide aptamer: a powerful potential tool in plant functional genomics[J].Hereditas,2010,32(6):548-554. |
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| Authors: | GONG Pi-Chang WANG Li HE Chao-Ying |
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| Institution: | State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China |
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| Abstract: | Aptamer is a newly invented tool for gene interference in vivo with highly specificity. An aptamer is designed to specifically target a protein and inhibit its biochemical roles for ascertaining its biological functions. Here, we briefly review the major progress of peptide aptamer in validating gene function, and emphasize its promising application in both plant functional genomics and peptide-mediated broad-spectrum plant resistance to diverse phytoviruses. The strategies to overcome the potential risks are covered as well. |
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| Keywords: | peptide aptamer chemical genetics protein interference functional genomics |
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