Differences in lipogenesis in tissues of control and gold-thioglucose obese mice after an isocaloric meal |
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Authors: | S C Blair G J Cooney G S Denyer P F Williams I D Caterson |
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Institution: | Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, N.S.W. Australia. |
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Abstract: | Lipogenesis was measured in 2 and 5 week gold-thioglucose (GTG) obese mice after a single meal of 0.5 g of standard chow. Compared to control mice the rate of lipogenesis in GTG obese mice, was 4-fold higher in liver and 10-fold higher in white adipose tissue (WAT). In brown adipose tissue (BAT) of GTG-injected mice the lipogenic rate was only 50% of that of controls. These results indicate that the increased lipid synthesis observed in GTG-injected mice is not due solely to hyperphagia and that some other stimuli, such as increased basal insulin levels and/or decreased thermogenesis and insulin resistance in BAT, contribute to the high rates of fat synthesis in this animal model of obesity. |
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