Comparative expression of endogenous retrotransposons in adult mouse mammary gland during normal development and differentiation |
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| Authors: | Harold L Asch Robert Z Vinci Jae Y Chang Farah Natoli Daniel L Stoler Garth R Anderson Bonnie B Asch |
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| Institution: | 1. Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark;2. Unit of Statistics and Data analysis, Danish Cancer Society Research Center, Copenhagen, Denmark;3. Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;1. Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea;2. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, South Korea;3. Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, South Korea;1. Breast Center, Integrated Surgical Institute, Cleveland Clinic, 9500 Euclid Avenue, A80, OH 44195, United States of America;2. Department of Medicine and Epidemiology and Population Health, Stanford University, 900 Blake Wilbur Drive, 1st Floor, Palo Alto, CA 94304, United States of America |
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| Abstract: | Amplified expression of the endogenous retrotransposons, intracisternal A particles (IAPs) and murine leukemia virus-related elements (MLVEs), along with decreased expression of VL30 elements frequently occurs during mouse mammary tumorigenesis. We have now analyzed the expression of these retroelements during the normal developmental and differentiation cycle of the mammary gland as found in virgin, pregnant, lactating, and post-lactation adult female BALB/c mice. Retrotransposon expression was either unchanged or decreased during the progressive stages of the cycle compared to virgin tissue. Likewise, growth of mammary epithelial cells in primary culture had little or no effect on expression of IAPs, MLVEs and VL30 sequences. Thus, the dramatic changes involving these retrotransposons in many mouse mammary tumors appear unrelated to any normal state. |
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