首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Staurosporine-induced morphological changes in the rat osteoblasts.
Authors:Rong-Sen Yang  Kuo-Shyan Lu  Wen-Mei Fu  Tang-Kue Liu  Shoei-Yn Lin-Shiau
Institution:1. Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan;2. Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan;3. Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;4. Department of Orthopedic Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan;5. Department of Orthopedic Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, Taiwan;1. Department of Psychology, Loyola Marymount University, 1 LMU Drive Suite 4700, Los Angeles, CA 90045 USA;2. Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA;1. Department of Orthopedic Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan;2. Cell Physiology and Molecular Image Research Center, Taipei Medical University׳s Wan-Fang Hospital, Taipei, Taiwan;3. Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan;4. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan;5. Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan;6. Anesthetics Toxicology Research Center, Taipei Medical University Hospital, Taipei, Taiwan;1. School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;2. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430073, China
Abstract:Treatment of cultured rat osteoblasts with staurosporine caused a rapid outgrowth of long slender cellular processes and the formation of stellate cells. The number of stellate cells increased with higher concentrations of and longer incubation with staurosporine. Scanning electron microscopy (SEM) revealed that the smooth surface of control polygonal cells became ruffled with many long slender cellular processes, thus increasing the cell surface area. Transmission electron microscopy (TEM) of the stellate cells showed a rich accumulation of large lipid droplets in the cytoplasm. Some lipid droplets had coalesced under the cytoplasmic membrane. We suggest that staurosporine has an effect on the differentiation of cultured rat osteoblasts.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号