Phagocytic activity of Dictyostelium amoebae treated with an organochlorine pesticide. |
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| Authors: | R. Gayatri S. Chatterjee |
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| Affiliation: | 1. Department of Microbiology, University College of Medical Sciences (University of Delhi) & Guru Teg Bahadur Hospital, Delhi 110095, India;2. Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan 45142, Saudi Arabia;3. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Al- Quwayiyah 19254, Riyadh, Saudi Arabia;4. Department of Biology, Arizona State University, Lake Havasu City, AZ 86403, USA;5. Scientific Research Centre, Prince Sultan Military Medical City, Riyadh 12486, Saudi Arabia;6. Department of Dermatology & STD, University College of Medical Sciences (University of Delhi) & Guru Teg Bahadur Hospital, Delhi 110095, India;7. Department of Biochemistry, University College of Medical Sciences (University of Delhi) & Guru Teg Bahadur Hospital, Delhi 110095, India;8. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia |
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| Abstract: | The effect of an organochlorine pesticide benzene hexachloride (containing α, β, γ and δ isomers) on the phagocytic activity of the vegetative cells of Dictyostelium discoideum was investigated. Benzene hexachloride (BHC) at concentrations of 60 ppm and above inhibited the phagocytic activity as revealed by 3H-labelled E. coli uptake. The BHC treated cells also showed smaller and delayed plaque formation. Interactions of lipophilic pesticide with the hydrophobic cell surface presumably alters the receptor mediated phagocytosis of Dictyostelium amoebae. |
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