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Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells. |
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| Authors: | Mamoru Isemura Yasuo Suzuki Ken Satoh Koh Narumi Masakichi Motomiya |
| Institution: | 1. Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;2. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA;3. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada;4. Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;5. Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;6. Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada;1. Department of Biochemistry, Institute of Molecular and Cell Biology, University of Tartu, Riia 23B, 51010 Tartu, Estonia;2. Laboratory of Biophysics, Institute of Physics, University of Tartu, W. Ostwaldi 1, 50411 Tartu, Estonia |
| Abstract: | We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL cells to the monolayer of bovine lung endothelial cells. (-)-Epicatechin gallate and (-)-epigallocatechin gallate were active in inhibiting the 3LL cell adhesion, while (+)-catechin and (-)-epicatechin were inactive. (-)-Epigallocatechin showed a considerable cytotoxicity. These data suggest that the specific chemical structure is required to exert the inhibitory activity of catechins and the search for the cellular binding protein(s) bound to these inhibitory catechins would provide a clue to clarify the mechanism of interactions between tumor cells and endothelial cells. |
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