Failure of sister chromatid separation leads to formation of diplochromosomes in colcemid treated PtK1 cells |
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| Authors: | Sibdas Ghosh Neidhard Paweletz Dieter Schroeter |
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| Affiliation: | 1. Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, Uttar Pradesh, India;2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, Uttar Pradesh, India;1. Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran;2. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;3. Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Student Research Committee, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;5. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran;1. Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Egypt;2. Pharmacology & Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, Egypt;1. Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea;2. Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup, Jeollabuk-do, Republic of Korea;3. College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea;4. Department of Biomedical Sciences, Ajou University School of Medicine, Suwon 16499, Republic of Korea;5. Graduate School of Biomedical Sciences, Ajou University School of Medicine, Suwon 16499, Republic of Korea;6. National Center for Efficacy Evaluation for Respiratory Disease, Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup, Jellobuk-do, Republic of Korea. |
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| Abstract: | The origin of diplochromosomes has been traced in multinucleate rat kangaroo cells (PtK1) obtained after colcemid treatment. In these cells the diplochromosomes were shown to originate from restitution nuclei, indicating that they were formed due to the omission or failure of sister chromatid separation and not due to endoreduplication. In this context the mechanism of sister chromatid separation has been discussed. The independence of this mitotic event from other associated processes, such as chromosome condensation, nuclear envelope breakdown or spindle formation has been stressed. |
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