Ultraviolet light modification of the prostaglandin receptor |
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Authors: | Malcolm Johnson Reginald Jessup Peter Ramwell |
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Institution: | Department of Physiology and Biophysics Georgetown University Washington, D. C. 20007, USA |
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Abstract: | Prostaglandin E1 elicits minimal inhibition of ultraviolet lightinduced platelet aggregation. Exposure to ultraviolet light progressively inhibits prostaglandin-induced responses in both the ADP-aggregating platelet and in uterine smooth muscle. This effect, which is cumulative and lasting, may be prevented or fully reversed by a sulfhydryl-oxidizing agent. Ultraviolet light may, therefore, initiate reduction of critical disulfide groups in the vicinity of the prostaglandin receptor. The technique of ultraviolet irradiation may serve as a useful tool in the specific determination of prostaglandins in biological systems. |
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