Akt/protein kinase B in skeletal muscle physiology and pathology |
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| Authors: | Miaozong Wu Marco Falasca Eric R. Blough |
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| Affiliation: | 1. Center for Diagnostic Nanosystems, Marshall University, Huntington, West Virginia;2. Department of Biological Sciences, Marshall University, Huntington, West Virginia;3. Department of Exercise Science, Sport and Recreation, College of Education and Human Services, Marshall University, Huntington, West Virginia;4. Queen Mary University of London, School of Medicine and Dentistry, BICMS, Centre for Diabetes, Inositide Signalling Group, London, UK;5. Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia |
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| Abstract: | The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while Akt over‐activation has been linked to inappropriate cell growth and proliferation. Although the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer. J. Cell. Physiol. 226: 29–36, 2010. © 2010 Wiley‐Liss, Inc. |
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