Protease inhibitor localization in control and streptozotocin-diabetic skeletal muscles |
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| Authors: | W T Stauber S H Ong V K Fritz F Esnard and F Gauthier |
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| Institution: | (1) Department of Physiology, West Virginia University Medical Center, 26506 Morgantown, WV, USA;(2) Laboratory of Biochemistry, Faculty of Medicine, 2 bis, Boulevard Tonnelle, F37032 Tours Cedex, France |
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| Abstract: | Summary  1-Antitrypsin and 1-inhibitor-3 were localized for the first time inside skeletal muscle cells. Their content, especially that of 1-inhibitor-3, was greatly reduced following streptozotocin-induced diabetes. 1-Antitrypsin and 1-inhibitor-3 were also observed in the vascular components and interstitial space surrounding both control and diabetic soleus muscles as revealed by immunofluorescence. In diabetic muscles, the non-myofibre locale of 1-inhibitor-3 was reduced, and to a lesser extent, 1-antitrypsin. Both myofibre and extracellular patterns were reversed to control levels by insulin replacement. |
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