Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids |
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| Authors: | Kostyuk Vladimir A Kraemer Tilo Sies Helmut Schewe Tankred |
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| Affiliation: | Institut für Physiologische Chemie I, Universit?tsklinikum Düsseldorf, Heinrich-Heine-Universit?t, P.O. Box 10 10 07, Germany. |
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| Abstract: | In the presence of a H(2)O(2)-generating system, myeloperoxidase (MPO) caused conjugated diene formation in low-density lipoprotein (LDL), indicating lipid peroxidation which was dependent on nitrite but not on chloride. The oxidation of LDL was inhibited by micromolar concentrations of flavonoids such as (-)-epicatechin, quercetin, rutin, taxifolin and luteolin, presumably via scavenging of the MPO-derived NO(2) radical. The flavonoids served as substrates of MPO leading to products with distinct absorbance spectra. The MPO-catalyzed oxidation of flavonoids was accelerated in the presence of nitrite. |
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