Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen |
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| Authors: | Park Byeoung-Soo Kim Dae-Young Rosenthal Philip J Huh Sun-Chul Lee Belinda J Park Eun -u Kim Sung-Min Kim Jang-Eok Kim Mi-Hee Huh Tae-Lin Choi Young-Jae Suh Ki-Hyung Choi Won-Sik Lee Sung-Eun |
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| Affiliation: | Department of Life Sciences, Soonchunhyang University, Asan-si, 336-600, Chungnam, Republic of Korea. |
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| Abstract: | In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum. |
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