| The role ofhepatitis B virus x gene in development of primary hepatocellular carcinoma |
| |
| 引用本文： | 陶小红,沈鼎明,任红,张晓实,张大志,古柏燕,叶珈. The role ofhepatitis B virus x gene in development of primary hepatocellular carcinoma[J]. 中国科学：生命科学英文版, 2000, 43(3): 293-301. DOI: 10.1007/BF02879289 |
| |
| 作者姓名： | 陶小红 沈鼎明 任红 张晓实 张大志 古柏燕 叶珈 |
| |
| 作者单位： | The first Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China |
| |
| 摘 要： | Primary hepatocellular carcinoma (HCC) is one of the most common cancers occurring in human, and there is strong epidemiological evidence suggesting that persistent hepatitis B virus (HBV) infection is the most important risk factor for its development. HBx gene was found to be a transactivator recently. Its continuous expression in hepatocytes may transactivate cellular genes which can play a certain role in development of HCC. The HBx gene fragment was used to construct a recombinant eukaryotic expression vector pCEP4 and introduced into HepG2 cells. The effect of HBx gene on HCC cells growth and its molecular mechanism in HCC cells regulation were investigated.
|
| 收稿时间： | 1999-11-17 |
The role of hepatitis B virus × gene in development of primary hepatocellular carcinoma |
| |
| Xiaohong Tao,Dingming Shen,Hong Ren,Xiaoshi Zhang,Dazhi Zhang,Baiyan Gu,Jia Ye. The role of hepatitis B virus × gene in development of primary hepatocellular carcinoma[J]. Science China Life sciences, 2000, 43(3): 293-301. DOI: 10.1007/BF02879289 |
| |
| Authors: | Xiaohong Tao Dingming Shen Hong Ren Xiaoshi Zhang Dazhi Zhang Baiyan Gu Jia Ye |
| |
| Affiliation: | (1) The first Affiliated Hospital, Chongqing University of Medical Sciences, 400016 Chongqing, China |
| |
| Abstract: | Primary hepatocellular carcinoma (HCC) is one of the most common cancers occurring in human, and there is strong epidemiological evidence suggesting that persistent hepatitis B virus (HBV) infection is the most important risk factor for its development. HBx gene was found to be a transactivator recently. Its continuous expression in hepatocytes may transactivate cellular genes which can play a certain role in development of HCC. The HBx gene fragment was used to construct a recombinant eukaryotic expression vector pCEP4 and introduced into HepG2 cells. The effect of HBx gene on HCC cells growth and its molecular mechanism in HCC cells regulation were investigated. |
| |
| Keywords: | HBx gene carcinogenesis hepatocellular carcinoma IGF-IR VEGF P21~(CIP1/WAF1) PCNA cell cycle. |
| 本文献已被 SpringerLink 等数据库收录！ |
| 点击此处可从《中国科学：生命科学英文版》浏览原始摘要信息 |
|
点击此处可从《中国科学：生命科学英文版》下载全文 |
