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Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists |
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| Authors: | Wendt John A Deeter Susan D Bove Susan E Knauer Christopher S Brooker Rachel M Augelli-Szafran Corinne E Schwarz Roy D Kinsora Jack J Kilgore Kenneth S |
| Institution: | Department of Medicinal Chemistry, Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. |
| Abstract: | A novel series of potent 2-aryl pyrido2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed. |
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