Cognitive Impairment in Chronic Obstructive Pulmonary Disease |
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Authors: | Alexandru F. Cri?an Cristian Oancea Bogdan Timar Ovidiu Fira-Mladinescu Alexandru Cri?an Voicu Tudorache |
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Affiliation: | 1. Department of Pulmonology, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania.; 2. Department of Biostatistics and Medical Informatics, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania.; 3. Department of Infectious Disease, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania.; Nathan Kline Institute and New York University School of Medicine, United States of America, |
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Abstract: | Background/PurposeChronic obstructive pulmonary disease (COPD), especially in severe forms, is commonly associated with multiple cognitive problems. Montreal Cognitive Assessment test (MoCA) is used to detect cognitive impairment evaluating several areas: visuospatial, memory, attention and fluency. Our study aim was to evaluate the impact of stable COPD and exacerbation (AECOPD) phases on cognitive status using MoCA questionnaire.MethodsWe enrolled 39 patients (pts), smokers with COPD group D (30 stable and 9 in AECOPD) and 13 healthy subjects (control group), having similar level of education and no significant differences regarding the anthropometric measurements. We analyzed the differences in MoCA score between these three groups and also the correlation between this score and inflammatory markers.ResultsPatients with AECOPD had a significant (p<0.001) decreased MoCA score (14.6±3.4) compared to stable COPD (20.2±2.4) and controls (24.2±5.8). The differences between groups were more accentuated for the language abstraction and attention (p<0.001) and delayed recall and orientation (p<0.001) sub-topics. No significant variance of score was observed between groups regarding visuospatial and naming score (p = 0.095). The MoCA score was significantly correlated with forced expiratory volume (r = 0.28) and reverse correlated with C-reactive protein (CRP) (r = −0.57), fibrinogen (r = −0.58), erythrocyte sedimentation rate (ESR) (r = −0.55) and with the partial pressure of CO2 (r = −0.47).ConclusionsAccording to this study, COPD significantly decreases the cognitive status in advanced and acute stages of the disease. |
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