Evaluation of microbial metabolites for trypanocidal activity: significance of biochemical and biological parameters in the mouse model of trypanosomiasis |
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| Authors: | A Kumar J N Dhuley S R Naik |
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| Institution: | Laboratory of Parasitology and Immunodiagnostics, Research Center, Hindustan Antibiotics Ltd, Pune, India. |
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| Abstract: | Trypanosomiasis is a parasitic disease, prevailing in both humans and animals, caused by a single-cell parasite, Trypanosoma spp. Three microbial metabolites, namely antiamoebin, F-857 and 6-MFA, were evaluated for trypanocidal activity by using a mouse model of trypanosomiasis, which is caused by T. evansi. The significance of the biological and biochemical parameters with respect to physio-pathology of trypanosomiasis and their implications in the evaluation of new trypanocidal compounds were discussed. |
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