Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice |
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| Authors: | Ohinata Kousaku Takagi Kuniko Biyajima Kyoko Fujiwara Yoko Fukumoto Shingo Eguchi Naomi Urade Yoshihiro Asakawa Akihiro Fujimiya Mineko Inui Akio Yoshikawa Masaaki |
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| Affiliation: | Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan. ohinata@kais.kyoto-u.ac.jp |
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| Abstract: | We found that prostaglandin (PG) D(2), the most abundant PG in the central nervous system, stimulates food intake after intracerebroventricular administration in mice. The orexigenic effect of PGD(2) was mimicked by a selective agonist for the DP(1) receptor among two receptor subtypes for PGD(2), and abolished by its antagonist. Central administration of an antagonist or antisense oligodeoxynucleotide for the DP(1) receptor remarkably decreased food intake, body weight and fat mass. Hypothalamic mRNA levels of lipocalin-type PGD synthase were up-regulated after fasting. The orexigenic activity of PGD(2) was also abolished by an antagonist for neuropeptide Y (NPY) Y(1) receptor. Taken together, PGD(2) may stimulate food intake through central DP(1) receptor coupled to the NPY system. |
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| Keywords: | PG, prostaglandin CNS, central nervous system L-PGDS, lipocalin-type prostaglandin D synthase ODN, oligodeoxynucleotide NPY, neuropeptide Y i.c.v., intracerebroventricular DMSO, dimethylsulfoxide ACSF, artificial cerebrospinal fluid COX, cyclooxygenase mPGES, microsomal prostaglandin E2 synthase |
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