Nucleotide sequence and organization of full length human U4 RNA pseudogenes |
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| Authors: | Christina Bark Ulf Pettersson |
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| Institution: | Department of Medical Genetics, Uppsala University, Biomedical Center, S-751 23, Uppsala, Sweden |
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| Abstract: | Two loci encoding human U4 RNA, designated U4/7 and U4/14, have been isolated and sequenced. Both are pseudogenes in that their sequences do not match any identified human U4 RNA species perfectly. The U4/7 locus harbours a full-length pseudogene of 144 bp with eight base substitutions in the structural region. This pseudogene might be derived from a hitherto unidentified human U4 RNA gene. The second locus, U4/14, has a complex structure; the structural sequence of a U4 gene has apparently been integrated into an Alu sequence. |
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| Keywords: | Alu-sequences gene family poly(A) tail recombinant DNA phage λ retroposon small nuclear RNA |
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