Cloning, structural organization, and chromosomal assignment of the porcine c-fos proto-oncogene, FOS |
| |
| Authors: | Reiner G Heinricy L Brenig B Geldermann H Dzapo V |
| |
| Institution: | Department of Animal Breeding and Biotechnology, University of Hohenheim, Stuttgart, Germany. g-reiner@uni-hohenheim.de |
| |
| Abstract: | The complete porcine c-fos proto-oncogene (FOS) with flanking regions was cloned and sequenced. FOS consists of four exons at amino acids 1-47, 48-131, 132-167, and 168-380 and includes all the typical motifs of the fos proto-oncogene. The promoter contains consensus sequences for CRE, SRE, CaRE, and the E-Box, as well as an AP-1 site. Homologies between human and swine were between 89.7% and 96.3% in the exons. Based on somatic cell hybrid panel screening and known homologies between swine chromosome 7 and human chromosome 14, the porcine c-fos gene was assigned to chromosome 7q23. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
