A novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation |
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Authors: | Michael Uhlin Mantas Okas Jens Gertow Mehmet Uzunel Torkel B Brismar Jonas Mattsson |
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Institution: | (1) Division of Clinical Immunology, Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, 141 52 Stockholm, Sweden;(2) CLINTEC, Department of Radiology, Karolinska University Hospital Huddinge, Stockholm, Sweden |
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Abstract: | Epstein–Barr virus (EBV)-related malignancies such as post-transplant lymphoproliferative disease (PTLD) are severe complications
after allogeneic stem cell transplantation and solid-organ transplantation. In immunosuppressed transplant recipients, the
activity of EBV-specific CTLs are often decreased or absent which leads to an increased risk of developing PTLD. If primary
treatment modalities of PTLD fail, the most efficient way of treating the malignancy is adopting EBV-specific CTLs from the
donor or, more recently, third-party donors. However, both are time consuming and expensive and often it is too late to administer
cells to the patient. We have for the first time, using a rapid isolation protocol of EBV-specific T cells, treated and cured
a patient suffering from PTLD with multiple-associated tissue lesions, using her haplo-identical mother as a donor. This treatment
approach paves way for a new possibility to within-days treat patients with life-threatening EBV-associated malignancies. |
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Keywords: | |
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