The characterization of conserved binding motifs and potential target genes for <Emphasis Type="Italic">M. tuberculosis</Emphasis> MtrAB reveals a link between the two-component system and the drug resistance of <Emphasis Type="Italic">M. smegmatis</Emphasis> |
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| Authors: | Yuqing Li Jumei Zeng Hua Zhang Zheng-Guo He |
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| Institution: | (1) National Key Laboratory of Agricultural Microbiology, Center for Proteomics Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China |
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| Abstract: | Background The two-component systems of Mycobacterium tuberculosis are apparently required for its growth and resistance in hostile host environments. In such environments, MtrAB has been
reported to regulate the expression of the M. tuberculosis replication initiator gene, dnaA. However, the dnaA promoter binding sites and many potential target genes for MtrA have yet to be precisely characterized. |
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