Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx |
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| Authors: | Buchanan Malcolm S Carroll Anthony R Fechner Gregory A Boyle Anthony Simpson Moana Addepalli Rama Avery Vicky M Forster Paul I Guymer Gordon P Cheung Tony Chen Huwei Quinn Ronald J |
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| Institution: | Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia. |
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| Abstract: | Isoprenylcysteine carboxyl methyltransferase (Icmt) is enzyme target in anticancer drug discovery. An Icmt natural product high-throughput screening campaign was conducted and a hit extract from the roots of Hovea parvicalyx was identified. 2'-Methoxy-3'-prenyl-licodione and 2'-methoxy-3',3'-diprenyl-licodione, two prenylated beta-hydroxychalcone compounds, together with the known flavanone (S)-glabrol, were isolated and identified as bioactive constituents. Their structures were determined largely by 1D and 2D NMR spectroscopy. |
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| Keywords: | Hovea parvicalyx Fabaceae β-Hydroxychalcone Isoprenylcysteine carboxyl methyltransferase (Icmt) 2′-Methoxy-3′-prenyl-licodione 2′-Methoxy-3′3′′-diprenyl-licodione Structure elucidation |
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