L-dopa inhibits in vitro phosphorylation of melanoma glycoproteins. |
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| Authors: | A Slominski T Friedrich |
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| Institution: | Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208. |
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| Abstract: | L-DOPA had no effect on the endogenous phosphorylation of proteins after extraction with 1% Triton X-100 from hamster melanoma. When proteins were purified further by wheat germ-agglutinin chromatography, however, a dramatic and dose-dependent inhibitory effect of DOPA on glycoprotein phosphorylation was observed in the presence of Mn+2. |
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