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Enzymatic synthesis of amino acid-sugar alcohol conjugates in organic media |
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| Authors: | Gyu-Jong Jeon Oh-Jin Park Byung-Ki Hur Ji-Won Yang |
| Institution: | (1) Department of Chemical Engineering, Korea Advanced Institute of Science and Technology, 373-1 Kusong-dong, Yusong-gu, Daejon, 305-701, South Korea;(2) LG Chemical Reseach Part, 104-1 Moonji-dong, Yusong-gu, Daejon, 305-701, South Korea;(3) School of Chemical, Polymer, and Biological Engineering, Inha University, Inchon, 402-751, South Korea |
| Abstract: | Amino acid-sugar alcohol conjugates were synthesized by a commercial serine protease, Optimase M-440, in organic media. Optimase M-440 showed broad substrate specificity towards N-t-Boc-protected l-amino acids as acyl donors and sugar alcohols as nucleophiles. Among various solvents tested Optimase M-440 showed the highest activity in pyridine. The regioselective acylation of the primary –OH groups of sugar alcohols gave the amino acid conjugates in good yields without byproducts. |
| Keywords: | amino acids Optimase M-440 sugar alcohols transesterification |
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