FOXO转录因子调控哺乳动物的细胞周期和凋亡

细胞周期和细胞凋亡是哺乳动物细胞生命活动的两大关键事件。FOXO在哺乳动物的细胞分化、增殖、生长、衰老等生命活动中发挥着重要的调控作用,并且参与细胞周期和凋亡的调控,是细胞生死的开关,因此FOXO已成为肿瘤、癌症科学研究的热点之一。在机体细胞中,FOXO受到上游信号分子PI3K/PKB、Ras等的激活或抑制从而调节下游信号分子FasL、Bim、p27kip1、cyclinG2、cyclinB、p130、GADD45等,并与其他细胞周期调控因子形成复杂的信号网络,调节哺乳动物细胞周期的进程和凋亡事件。

Mediation of the Cell Cycle and Apoptosis by FOXO Transcriptional Factors in Mammals

Cell cycle and apoptosis are two curial events in the mammalian cell. FOXO plays a critical role in cell proliferation, growth, reproduction, and aging in mammals. FOXO induces the cell proliferation and controls the cell cycle, is a switch between survive and death of cells. Recent years, lots of researchers are engaging in FOXO on tumor and cancer. Some signal pathways including PI3K/PKB, Ras regulate the FOXO, FOXO in turn regulate the signal molecular downstreams, such as, FasL, Bim, p27kip1, cyclin G2, cyclin B, p130 and GADD45. FOXO and other cell cycle regulators join as a complex network of cell signals and then control the progress of cell cycle.