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Advances and challenges in understanding histone demethylase biology
Affiliation:1. Structural Genomics Consortium, University of Oxford, Headington OX3 7DQ, UK;2. Botnar Research Centre, NIHR Oxford Biomedical Research Unit, Oxford OX3 7LD, UK;3. Target Discovery Institute, University of Oxford, OX3 7FZ, UK;4. Department of Chemistry, University of Oxford, OX1 3TA, UK;5. Pfizer Worldwide Medicinal Chemistry, 610 Main Street, Cambridge, MA 02139, USA;1. Department of Otorhinolaryngology–Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA;2. The Wistar Institute, Philadelphia, PA 19104, USA;3. Philadelphia VA Medical Center, Philadelphia, PA 19104, USA;1. Department of Surgery, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;2. Department of Tumor Cell Biology, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;3. Department of Oncology, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;4. Department of Computational Biology, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;5. Department of Clinical Laboratory, Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao 266033, China;6. Department of Clinical Laboratory, Qingdao Central Hospital, Affiliated Hospital of Qingdao University, Qingdao 266042, China;7. Department of Molecular Biosciences, University of Texas at Austin, 100 E 24th St NHB 2.606 Stop A5000, Austin, TX 78712, USA;8. Department of Biostatistics, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;9. Department of Pathology, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;10. Department of Chemical Biology and Therapeutics, St Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;11. Department of Pathology, Yale School of Medicine, 310 Cedar St, New Haven, CT 06520, USA;1. Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA;2. Department of Neuroscience, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA;3. Department of Cancer Biology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA;4. Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC V6T 1Z4, Canada;1. Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;2. Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA;1. Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, 300071, PR China;2. West China Hospital, Sichuan University, Chengdu, 610041, PR China;1. Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK;2. Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK;3. NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK;4. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK;5. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7BN, UK;6. Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK;7. Division of Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK;8. University of Arkansas for Medical Sciences, Myeloma Institute, 4301 W. Markham #816, Little Rock, AR 72205, USA
Abstract:
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