Parallel increases in rates of fatty acid synthesis and in pyruvate dehydrogenase activity in isolated rat hepatocytes incubated with insulin |
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| Authors: | Françoise Assimacopoulos-Jeannet James G McCormack Marc Prentki Bernard Jeanrenaud Richard M Denton |
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| Institution: | 1. Laboratoires de Recherches Métaboliques, 64 Avenue de la Roseraie, Département de Médecine, Geneva, Switzerland;2. Department of Biochemistry, University Walk, Bristol BS8 1TD, U.K. |
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| Abstract: | The effect of insulin on the activity of pyruvate dehydrogenase is studied in isolated hepatocytes from fed rats. Insulin increases the ‘initial’ activity of pyruvate dehydrogenase by 30% without modifying the total activity of the enzyme. The maximal increase is reached 3 min after addition of the hormone and is dose-dependent. Insulin also increases the rate of fatty acid synthesis. |
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| Keywords: | Fatty acid synthesis Pyruvate dehydrogenase Insulin (Rat hepatocyte) |
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