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Microencapsulation of erythrocytes
Authors:Michael V Sefton  Richard L Broughton
Institution:Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 1A4 Canada
Abstract:Human erythrocytes have been encapsulated in a polyacrylate membrane by a simple precipitation process. The encapsulated cells appeared to remain functional after encapsulation: the consumption of glucose and the ability to reversibly bind oxygen was unimpaired. Furthermore, storage at 4°C for almost 6 months had no effect on the P50 and n50 values. This is the first time to our knowledge that live mammalian cells have been encapsulated in a polymer other than alginate.
Keywords:Encapsulation  Erythrocyte  Polyacrylate membrane
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