| 心外膜应用腺苷时c—fos在脊髓延髓和丘脑中的表达 |
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| 引用本文： | 马秀英,张连珊.心外膜应用腺苷时c—fos在脊髓延髓和丘脑中的表达[J].生理学报,1997,49(4):395-399. |
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| 作者姓名： | 马秀英 张连珊 |
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| 作者单位： | 河北医科大学基础医学研究所生理室!石家庄，050017，河北医科大学基础医学研究所生理室!石家庄，050017，河北医科大学基础医学研究所生理室!石家庄，050017 |
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| 基金项目： | 河北省自然科学基金!396153 |
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| 摘 要： | 在１２只切断两侧缓冲神经和迷走神经的麻醉大鼠，观察了心外膜应用腺苷对脊髓，延髓和丘脑ｃ－ｆｏｓ原部基因表达的影响。结果显示：心外膜应用腺苷组大鼠，动脉血压和心率无明显变化；脊髓Ｔ３节段背角，延髓巨细胞旁外侧核以及丘脑的腹后外侧核，后核，中央外侧核和束旁核等部位Ｆｏｓ蛋白样免疫阳性反应神经元显著增加；而在溶剂对照组大鼠，仅见少数ＦＬＩ细胞。
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| 关 键 词： | 脊髓 延髓 丘脑 腺苷 Fos蛋白 |
EXPRESSION OF c-fos IN SPINAL CORD,MEDULLA OBLONGATA AND THALAMUS FOLLOWING EPICARDIAL APPLICATION OF ADENOSINE |
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| MA XIU-YING,ZHANG LIAN-SHAN,HE RUI-RONG.EXPRESSION OF c-fos IN SPINAL CORD,MEDULLA OBLONGATA AND THALAMUS FOLLOWING EPICARDIAL APPLICATION OF ADENOSINE[J].Acta Physiologica Sinica,1997,49(4):395-399. |
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| Authors: | MA XIU-YING ZHANG LIAN-SHAN HE RUI-RONG |
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| Abstract: | Effects of epicardial application of adenosine on the expression of c-fos proto-oncogene in spinal cord, medulla oblongata and thalamus were examined in 12 sinoaorticdenervated and vagotomized anesthetized rats. The results showed that following epicardial application of adenosine the Fos-like protein immunoreactive (FLI) neurons wereremarkably increased in the dorsal horn of T3 spinal segment, nucleus paragigantocellularis lateralis (PGL) of medulla oblongata, ventral postero-lateral thalamic nueleus(VPL), posterior thalamic nucleus (Po), parafascicular thalamic nucleus (PF) and centrolateral thalamic nucleus (CL), while the blood pressure and heart rate were not affected. Only a few FLI neurons were found in the vehicle-control rats. The results indicate that epicardial application of adenosine may activate the pain-related neurons inspinal cord, medulla oblongata and thalamus. |
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| Keywords: | adenosine Fos protein spinal cord medulla oblongata thalamus |
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