鼠伤寒沙门菌入侵宿主细胞机制研究进展*

鼠伤寒沙门菌(Salmonella typhimurium)是一种人畜共患的肠道病原菌,可引起肠道炎症。该病原菌主要通过其致病岛(SPIs)编码的III型分泌系统(T3SS)分泌效应因子,包括促炎因子和抗炎因子。其在入侵肠上皮细胞时会释放促炎因子引发炎症反应,同时,为防止促炎因子过度破坏宿主细胞影响菌体的生存和繁殖,鼠伤寒沙门菌会产生一系列抗炎因子来调节细胞内信号通路,与宿主共同繁殖并最终全身扩散造成严重感染。旨在对鼠伤寒沙门菌利用T3SS效应因子入侵并调节宿主细胞信号通路机制进行概述。

Research Progress on the Salmonella typhimurium Invading Host Cells

Salmonella typhimurium is a zoonotic intestinal pathogen, which can cause intestinal inflammation. Effectors are mainly secreted through the type III secretion system(T3SS) encoded by its pathogenic islands (SPIs) to invade host cells and regulate cell signaling pathways, including pro-inflammatory effectors and anti-inflammatory factors. Pro-inflammatory effectors are released to cause inflammation when Salmonella typhimurium invades intestinal epithelial cells. In order to prevent excessive damage of host cells by pro-inflammatory effectors affecting the survival and reproduction of bacteria, Salmonella typhimurium can produce a series of anti-inflammatory factors to regulate intracellular signaling pathways, co-produce with the host and eventually spread throughout the body to cause severe infection. This paper provides an overview of the mechanism by which Salmonella typhimurium utilizes T3SS effectors to invade host cells and regulate cell signaling pathways.