Logic regression analysis of association of gene polymorphisms with low HDL: Tehran Lipid and Glucose Study |
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Authors: | Parvin Sarbakhsh Yadollah Mehrabi Maryam Sadat Daneshpour Farid Zayeri Maryam Zarkesh |
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Institution: | 1. Department of Biostatistics, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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Abstract: | IntroductionLogic regression is a generalized regression method that can recognize complex Boolean interactions of binary variables. It has been successfully applied to single-nucleotide polymorphism (SNP) data because of the importance of interactions in SNP association studies. The objective of this study is to assess the association between high-density lipoprotein (HDL) function and some related gene polymorphisms after adjusting for potential confounders using logic regression.MethodsSubjects in this cross-sectional study were randomly selected from among participants of the Tehran Lipid and Glucose Study (TLGS). A total of 436 subjects (172 men and 264 women), aged ≥ 20 years, were selected to be included in the current study. Logic regression analysis was used in order to recognize the combination of genetic main effects and possible interactions associated with HDL-C level. Cross validation and randomization test were carried out to avoid over fitting of the models.ResultsThe cross validation test suggested three Boolean combinations with four predictors for a fully-adjusted logic model. The fully adjusted model showed that those who carry an Apo E gene E3 allele or have high TG level have an odds ratio of 2.35 (95% CI:1.3–4.25) for having low HDL compared to other subjects. In addition, subjects with high TG level have an odds ratio of 2.73 (95% CI: 1.65, 4.53) for having low HDL.ConclusionThe results showed that logic regression is a powerful method to find the interaction between high TG level and Apo E polymorphism associated with low HDL. |
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Keywords: | SNP Single-Nucleotide Polymorphism HDL High-Density Lipoprotein TLGS Tehran Lipid and Glucose Study TG Triglycerides WC Waist Circumference FBS Fasting Blood Sugar BP Blood Pressure Apo Apolipoprotein Apo A1M1 Apolipoprotein A1M1 ApoA1M2 Apolipoprotein A1M2 APOB Apolipoprotein B ApoAIV Apolipoprotein AIV ApoCIII Apolipoprotein CIII ApoE Apolipoprotein E ABCA1 Adenosine triphosphate-Binding Cassette A1 SRB1 Scavenger Receptor Class B type 1 |
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