Association of eNOS polymorphisms (-786T>C, 4a4b, 894G>T) with colorectal cancer susceptibility in the Korean population |
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Authors: | Moon Ju Jang Young Joo Jeon Jong Woo Kim So Young Chong Sung Pyo Hong Doyeun Oh Yun Kyung Cho Ki Wha Chung Nam Keun Kim |
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Affiliation: | 1. Department of Internal Medicine, School of Medicine, CHA University, Seongnam, South Korea;2. Institute for Clinical Research, School of Medicine, CHA University, Seongnam, South Korea;3. Department of Surgery, School of Medicine, CHA University, Seongnam, South Korea;4. Department of Internal Medicine, CHA Gangnam Medical Center, School of Medicine, CHA University, Seoul, South Korea;5. Department of Biological Science, College of Natural Science, Kongju National University, Kongju, South Korea |
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Abstract: | BackgroundPolymorphisms of endothelial nitric oxide synthases (eNOS) have been shown to be associated with cancer susceptibility. However, the results of such studies are conflicting to date. We investigated whether polymorphisms of the eNOS gene correlated with patients with colorectal cancer (CRC), relative to healthy individuals.Patients and methodsIn the present study, we analyzed three polymorphisms of eNOS (-786T>C, 4a4b, and 894G>T) in 509 healthy controls and 528 patients with CRC. The genotyping of eNOS polymorphisms was performed using polymerase chain reaction or polymerase chain reaction–restriction fragment length polymorphism assays.ResultsWe found that the TC+CC genotype of the -786T>C polymorphism was significantly associated with an increased risk of CRC compared with the TT genotype. Similarly, the GT+TT genotype of the 894G>T polymorphism was associated with an increased susceptibility to CRC. However, no evidence was found for any association between the 4a4b polymorphism and CRC risk. In addition, the C/4b/G (-786T>C/4a4b/894G>T) haplotype was significantly associated with increased risk of CRC and C/4b/T (-786T>C/4a4b/894G>T) haplotype was only detected in CRC patients.ConclusionsOur study suggests that the eNOS -786T>C and 894G>T polymorphisms may be associated with the development of CRC in the Korean population. |
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Keywords: | NO, nitric oxide eNOS, endothelial nitric oxide synthases nNOS, neuronal nitric oxide synthases iNOS, inducible nitric oxide synthases CRC, colorectal cancer HTN, hypertension DM, diabetes mellitus COR, crude odds ratio AOR, adjusted odds ratio 95% CI, 95% confidence interval |
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