VDR TaqI is associated with obesity in the Greek population |
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Authors: | Yiannis Vasilopoulos Theologia Sarafidou Kalliopi Kotsa Maria Papadimitriou Yiannis Goutzelas Costas Stamatis Vasilis Bagiatis Xanthi Tsekmekidou John G. Yovos Zissis Mamuris |
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Affiliation: | 1. Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece;2. Division of Endocrinology and Metabolism, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece |
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Abstract: | The prevalence of obesity has increased dramatically during the last thirty years in western countries with severe complications for health and economy. Obesity is the outcome of the strong interplay between genetic and environmental factors and is therefore widely expected that the discovery of the many genetic factors underlying the heritable risk of obesity will contribute critically to our basic knowledge of the disease etiopathogenesis and the identification of new targets for therapeutic intervention. The aim of the present study was to assess the genetic contribution of known polymorphisms in two genes that are linked to the pathogenetic mechanism of obesity. Analysis of vitamin D receptor (VDR) TaqI (rs731236; T/C) and fat mass and obesity-associated (FTO) (rs9930506; A/T) polymorphisms in 82 obesity subjects and 102 controls showed significant association for VDR TaqI ‘T’ allele and obesity (OR: 2.07; 1.123–3.816; P = 0.019), contributing to an elevated BMI of 3 kg/m2 per risk allele. No association was observed for the FTO polymorphism. These results further support a role for VDR as risk factor for obesity and suggest its further validation in larger independent populations as well as highlight a target for functional analysis towards therapeutic intervention in obese individuals. |
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Keywords: | VDR, vitamin D receptor FTO, fat mass and obesity-associated T2DM, Type 2 Diabetes mellitus SNP, single nucleotide polymorphism |
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