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DISC1-related signaling pathways in adult neurogenesis of the hippocampus |
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| Authors: | Qian Wu Yi Li Bo Xiao |
| Institution: | Department of Neurology, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan, 410008, China |
| Abstract: | Disrupted-in-schizophrenia 1 (DISC1) is a multifunctional scaffold protein which plays an important role in neurogenesis and neural development in the adult brain, especially in the dentate gyrus (DG) of the hippocampus. Accumulated research has unveiled the role of DISC1 in several aspects of neural development and neurogenesis, such as neuronal maturation, proliferation, migration, positioning, differentiation, dendritic growth, axonal outgrowth, and synaptic plasticity. Studies on the function of this protein have explored multiple facets, including variants and missense mutants in genetics, proteins interactivity and signaling pathways in molecular biology, and pathogenesis and treatment targets of major mental illness, and more. In this review, we present several signaling pathways discussed in recent research, such as the AKT signaling pathway, GABA signaling pathway, GSK3β signaling pathway, Wnt signaling pathway, and NMDA-R signaling pathway. DISC1 interacts, directly or indirectly, with these signaling pathways and they co-regulate the process of adult neurogenesis in the hippocampus. |
| Keywords: | BP Bipolar disorder CA Cornu ammonis CNS Central nervous system CPP 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid CT Carboxyterminal DG Dentate gyrus DGCs Dentate granule cells DISC Disrupted-in-schizophrenia 1 Dixdc1 Dix domain containing 1 FEZ1 Elongation Protein Zeta-1 Fz Frizzled GABA γ-aminobutyric acid Grb2 Growth factor receptor bound protein 2 GSK3β Glycogen synthase kinase 3β KCC2 K+&ndash Cl&minus co-transporter 2 kDa kilodalton KIF5B Kinesin family members 5B LEF/TCF Lymphoid enhancer factor/T cell factor LIS1 Lissencephaly-1 LRP5/6 Lipoprotein receptor-related protein 5/6 MDD Major depressive disorder MK-801 (5R 10S)-(+)-5-Methyl-10 11-dihydro-5H-dibenzo[a d]c-cyclohepten-5-10-imine hydrogen maleate MW Molecular weight NDEL1 Nuclear distribution gene E-like homolog 1 NKCC1 Na+-K+-Cl&minus co-transporter1 NLS Nuclear localization signal NMDA-R N-methyl-d-aspartate-type glutamate receptor NSCs Neural stem cells NT Unique amino NT-3 Neutrophins-3 OB Olfactory bulbs PTEN Phosphatase and tensin homolog deleted on chromosome ten RNAi RNA interference RYK Related to tyrosine kinase SGZ Subgranular zone shRNA Short hairpin RNA siRNA Small interference RNA SVZ Subventricular zone SZ Schizophrenia |
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