The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk of uterine leiomyoma (ULM) |
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| Authors: | Yi Feng Xitong Zhao Chunfen Zhou Lu Yang Yingwei Liu Ce Bian Jinhai Gou Xiaojuan Lin Zhenling Wang Xia Zhao |
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| Institution: | 1. Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Chengdu 610041, Sichuan, PR China;2. West China Medical School, Sichuan University, Chengdu 610041, Sichuan, PR China;3. The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China |
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| Abstract: | The Val158Met polymorphism of the COMT gene has been implicated in susceptibility to uterine leiomyoma (ULM), but the reported results were inconclusive. The aim of the study was to evaluate the Val158Met polymorphism of the COMT gene and the risk of ULM by meta-analysis. A comprehensive electronic search for relevant articles was conducted in Pubmed, Embase, CNKI, Wanfang, and Weipu databases. Statistical analysis was performed by using the Revman4.2 software and Stata10.0 software. A total of 7 articles including 12 case–control studies were identified in this meta-analysis. The results showed that the polymorphism was associated with decreased risk of ULM (Met/Met + Val/Met vs. Met/Met: OR = 0.84, 95% CI = 0.70–0.99, Z = 2.07, p = 0.04). In the subgroup analyses by ethnicity, significant decreased risk was found among the black populations (OR = 0.68, 95% CI = 0.48–0.97, Z = 2.15, p = 0.03). The current meta-analysis suggested that the Val158Met polymorphism in the COMT gene was associated with decreased risk of ULM, especially in the black population. Future studies are needed to validate our conclusions. |
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| Keywords: | COMT gene catechol-O-methyltransferase gene ULM uterine leiomyoma COMT Catechol-O-methyltransferase GWA genome-wide association OR odds ratio CI confidence interval Z Z value for Q statistic p p-value for Q statistic I I statistic for heterogeneity Phet p value for heterogeneity F fixed model |
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