The effect of folate-related SNPs on clinicopathological features,response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients |
| |
| Authors: | Nataliya Babyshkina Elena Malinovskaya Mariya Nazarenko Mariya Koval Polina Gervas Olga Potapova Elena Slonimskaya Nadejda Cherdyntseva |
| |
| Affiliation: | 1. Department of Experimental Oncology, Cancer Research Institute of Siberian Branch of Russian Academy of Medical Sciences, Tomsk, 634050, Russian Federation;2. Department of General Oncology, Cancer Research Institute of Siberian Branch of Russian Academy of Medical Sciences, Tomsk, 634050, Russian Federation;3. Research Institute of Medical Genetics of Siberian Branch of Russian Academy of Medical Sciences, Tomsk, 634050, Russian Federation;4. Cureline, Inc., South San Francisco, CA 94080, USA |
| |
| Abstract: | This study aimed to investigate the relationship of ten single nucleotide polymorphisms (SNPs) in the MTHFR, MTR, MTRR, DHFR, MTHFD1, TS, RFC1 and DNMT3b genes with cancer survival, therapeutic response to neoadjuvant chemotherapy and clinicopathological characteristics in 300 pre- and postmenopausal breast cancer patients of a Russian Western Siberian population. We found that the MTHFR 677CT genotype as well as combination of MTHFR 677CT and 677TT genotype was related to tumor size and estrogen-positive status in postmenopausal group. The RFC1 80А allele was associated with an increased risk of lymph node metastases among postmenopausal women. The MTHFR 677TT genotype was significantly correlated with a better progression-free survival in premenopausal patients. In contrast, a worse outcome was observed in this group patient with MTHFD1 1958AA genotype. In the multivariate analysis, the MTHFD1 1958AA genotype was identified as an independent prognostic factor for premenopausal breast cancer survival. Our findings provide evidence for associations of breast cancer survival with folate-related SNPs in a population of Western Siberian region of Russia and the MTHFD1 (1958G>A) may have additional prognostic value especially among premenopausal patients. |
| |
| Keywords: | BMI, body mass index 95% CI, confidence intervals CMF, cyclophosphamide, methotrexate and 5-fluorouracil DNMT3b, DNA methyltransferase DHFR, dihydrofolate reductase ER, estrogen receptor FAC, 5-fluorouracil, adriamycin and cyclophosphamide HER2, human epidermal growth factor receptor 2 MTHFD1, methylenetetrahydrofolate dehydrogenase MTHFR, methylenetetrahydrofolate reductase MTR, methionine synthase MTRR, methionine synthase reductase OR, odds ratios PCR-RFLP, polymerase chain reaction restriction fragment length polymorphism PFS, progression-free survival PR, progesterone receptor RFC1, reduce folate carrier 1 SNP, single nucleotide polymorphism TS, thymidylate synthetase |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
